Genome-wide dissection of genotype-phenotype relationships
This project systematically analyzes complex genotype-phenotype relationships in the longitudinal course of schizophrenia and bipolar disorder. These analyses are based on a large sample comprising 3,200 prospectively-followed patients and prospectively-followed 1,200 controls, for all of whom we are generating genome-wide SNP and CNV data. A replication design is adopted and we use sophisticated genetic-statistic tools to identify robust genotype-phenotype signatures, including gene-environment interaction We additionally are establishing a platform for longitudinal biological psychiatric research, which is woven into both the administrative and clinical infrastructure of the Department of Psychiatry and Psychotherapy and 13 collaborating clinical centers (incl. academic teaching hospitals). Any patient suffering from psychosis being treated in the inpatient and outpatients sections of the Department will be able to participate in our longitudinal research, comprising in-depth psychopathological, neuropsychological, pharmacological assessment as well as brain imaging.
We will establish both a phenome database and a biobank for genomic, transcriptomic, and proteomic studies, thus creating one of the largest European resources for research in the longitudinal course of psychosis.